Intracoronary mitochondrial transplantation
نویسندگان
چکیده
منابع مشابه
[Intracoronary stem cell transplantation in acute myocardial infarction].
INTRODUCTION AND OBJECTIVES Experimental and clinical studies suggest that necrotic myocardium may have the capacity to regenerate. We have started a clinical study to demonstrate that the intracoronary implantation of stem cells is feasible and safe. The results in our first 5 patients are presented here. PATIENTS AND METHOD We included patients with anterior acute myocardial infarction and ...
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متن کاملMitochondrial transplantation for therapeutic use.
Mitochondria play a key role in the homeostasis of the vast majority of the body's cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obstruction of blood flow and as a result oxygen delivery to myocardial cells (ischemia) severely alters mitochondrial structure and function. These alterations in mitochondrial structure and ...
متن کاملMitochondrial transplantation attenuates hypoxic pulmonary vasoconstriction
Hypoxia triggers pulmonary vasoconstriction, however induces relaxation of systemic arteries such as femoral arteries. Mitochondria are functionally and structurally heterogeneous between different cell types. The aim of this study was to reveal whether mitochondrial heterogeneity controls the distinct responses of pulmonary versus systemic artery smooth muscle cells to hypoxia. Intact mitochon...
متن کاملMitochondrial transplantation attenuates hypoxic pulmonary hypertension
Mitochondria are essential for the onset of hypoxia-induced pulmonary vasoconstriction and pulmonary vascular-remodeling, two major aspects underlying the development of pulmonary hypertension, an incurable disease. However, hypoxia induces relaxation of systemic arteries such as femoral arteries and mitochondrial heterogeneity controls the distinct responses of pulmonary versus femoral artery ...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2020
ISSN: 1759-5002,1759-5010
DOI: 10.1038/s41569-020-0340-9